Polyphenol levels in human urine after intake of six different polyphenol-rich beverages.
Identifieur interne : 002691 ( Main/Exploration ); précédent : 002690; suivant : 002692Polyphenol levels in human urine after intake of six different polyphenol-rich beverages.
Auteurs : Hideyuki Ito [France] ; Marie-Paule Gonthier ; Claudine Manach ; Christine Morand ; Louise Mennen ; Christian Rémésy ; Augustin ScalbertSource :
- The British journal of nutrition [ 0007-1145 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Beverages, Biomarkers (urine), Cacao, Caffeine, Calibration, Case-Control Studies, Chromatography, High Pressure Liquid, Citrus paradisi, Citrus sinensis, Coffee, Diet, Female, Flavonoids (administration & dosage), Flavonoids (chemistry), Flavonoids (urine), Humans, Male, Phenols (administration & dosage), Phenols (chemistry), Phenols (urine), Polyphenols, Sensitivity and Specificity, Spectrometry, Mass, Electrospray Ionization, Statistics, Nonparametric, Tea, Theobromine, Time Factors.
- MESH :
- chemical , administration & dosage : Flavonoids, Phenols.
- chemical , chemistry : Flavonoids, Phenols.
- chemical , urine : Biomarkers, Flavonoids, Phenols.
- Adult, Beverages, Cacao, Caffeine, Calibration, Case-Control Studies, Chromatography, High Pressure Liquid, Citrus paradisi, Citrus sinensis, Coffee, Diet, Female, Humans, Male, Polyphenols, Sensitivity and Specificity, Spectrometry, Mass, Electrospray Ionization, Statistics, Nonparametric, Tea, Theobromine, Time Factors.
Abstract
Dietary polyphenols are suggested to participate in the prevention of CVD and cancer. It is essential for epidemiological studies to be able to compare intake of the main dietary polyphenols in populations. The present paper describes a fast method suitable for the analysis of polyphenols in urine, selected as potential biomarkers of intake. This method is applied to the estimation of polyphenol recovery after ingestion of six different polyphenol-rich beverages. Fifteen polyphenols including mammalian lignans (enterodiol and enterolactone), several phenolic acids (chlorogenic, caffeic, m-coumaric, gallic, and 4-O-methylgallic acids), phloretin and various flavonoids (catechin, epicatechin, quercetin, isorhamnetin, kaempferol, hesperetin, and naringenin) were simultaneously quantified in human urine by HPLC coupled with electrospray ionisation mass-MS (HPLC-electrospray-tandem mass spectrometry) with a run time of 6 min per sample. The method has been validated with regard to linearity, precision, and accuracy in intra- and inter-day assays. It was applied to urine samples collected from nine volunteers in the 24 h following consumption of either green tea, a grape-skin extract, cocoa beverage, coffee, grapefruit juice or orange juice. Levels of urinary excretion suggest that chlorogenic acid, gallic acid, epicatechin, naringenin or hesperetin could be used as specific biomarkers to evaluate the consumption of coffee, wine, tea or cocoa, and citrus juices respectively.
PubMed: 16197573
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Dietary polyphenols are suggested to participate in the prevention of CVD and cancer. It is essential for epidemiological studies to be able to compare intake of the main dietary polyphenols in populations. The present paper describes a fast method suitable for the analysis of polyphenols in urine, selected as potential biomarkers of intake. This method is applied to the estimation of polyphenol recovery after ingestion of six different polyphenol-rich beverages. Fifteen polyphenols including mammalian lignans (enterodiol and enterolactone), several phenolic acids (chlorogenic, caffeic, m-coumaric, gallic, and 4-O-methylgallic acids), phloretin and various flavonoids (catechin, epicatechin, quercetin, isorhamnetin, kaempferol, hesperetin, and naringenin) were simultaneously quantified in human urine by HPLC coupled with electrospray ionisation mass-MS (HPLC-electrospray-tandem mass spectrometry) with a run time of 6 min per sample. The method has been validated with regard to linearity, precision, and accuracy in intra- and inter-day assays. It was applied to urine samples collected from nine volunteers in the 24 h following consumption of either green tea, a grape-skin extract, cocoa beverage, coffee, grapefruit juice or orange juice. Levels of urinary excretion suggest that chlorogenic acid, gallic acid, epicatechin, naringenin or hesperetin could be used as specific biomarkers to evaluate the consumption of coffee, wine, tea or cocoa, and citrus juices respectively.</div>
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